Transparency International’s (TI) regional departments were created to provide a strong network for anti-corruption initiatives and co-operation at regional level. The regional departments support the work done by TI's National Chapters around the world, provide a platform for sharing knowledge and experience, develop strategies to respond to regionally distinct patterns of corruption and initiate advocacy campaigns at both the regional and sub-regional level. The regional departments also play an important role in advancing TI’s global priorities in the fight against corruption.

TI National Chapters in the region have become an integral pillar of national integrity in their respective countries, despite the challenges frequently faced by civil society activists in this part of the world. In recent years, the Chapters have been furthering the anti-corruption cause by demanding greater accountability from government and advocating far-reaching reforms in various areas of governance, ranging from the management of public resources to increased transparency in the private sector. These national civil society coalitions active in the fight against corruption play a vital role in strengthening democracy and participation, raising awareness and lobbying for landmark legislation such as the UNCAC in some of the regions' young democracies.

The Americas Department at the Transparency International Secretariat represents 15 National Chapters and contacts groups in both North, Central and South America. While united in the common goal of fighting corruption, both sides of the hemisphere must advance the anti-corruption struggle in different contexts. For example, while the fight against corruption in North America has been marked primarily by accounting, financial and political scandals; Latin American countries continue to suffer from structural problems that affect the region’s economic and democratic development.

The Asia Pacific region represents more than half of the world’s population and is marked by it's diversity in terms of cultural, social and political background. TI's Asia-Pacific Department provides support to 20 National Chapters and contact groups across the region.

From Ireland to Mongolia, the Europe and Central Asia region is composed of countries wildly diverse in terms of history, culture, and economic and political development. As a result of this diversity is also a marked difference in the level and type of corruption each country must face in its national context. The Europe and Central Asia Department at TI was created to help bridge these differences by sharing information, lessons learned and resources developed by its National Chapters in the region. The department currently works with 40 National Chapters and contact groups; which have been functionally divided into three sub-regions based upon both EU status and geographical proximity: EU and EFTA Member States plus Israel; South East Europe and West CIS, and Central Asia, Russia and Caucasus.

The TI EU Office liaises with European Union institutions to promote the fight against corruption. Its main activities are to advocate for improvement in policy, legislation and programmes. All activities are embedded in Transparency International's global priorities and the related thematic issues.The TI Liaison Office to the EU is part of the International Secretariat of TI and works in close cooperation with the entire global movement, which consists of close to 100 national chapters worldwide. The TI EU Office coordinates TI’s EU-relevant anti-corruption work, carried out by national chapters within and outside of the EU. Special emphasis is placed on the cooperation among the 22 TI national chapters in EU Member States, the seven national chapters in EU accession candidate countries and the International Secretariat in Berlin. To contact the TI secretariat's regional department for more information about work in the European region, please see the site of the Europe and Central Asia Department.